Fragen Über haass Revealed
Fragen Über haass Revealed
Blog Article
Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.
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Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for the DZNE Munich, is known for his groundbreaking research rein Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease hinein order to gain fundamental insights into its development.
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Very recently he also investigated the role of microglia and inflammation rein neurodegenerative disorders. This work Lumineszenzdiode to the spectacular finding that microglial phagocytosis may be impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms. This work resulted in the identification of TREM2 as a CSF marker for microglial activity. Rein a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 was abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.
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If you are lacking driving practice or simply haven't driven a car rein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.